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Research projects

The Trust has funded a wide range of research projects which are listed below by subject area. Reports are available to download where indicated.

Viral Hepatitis

Antigen Presentation in HBV Infection
Miss S Shanmuganathan – St Mary’s Hospital, London
Final report

Alcohol

Alcohol Research Fellowship
Dr Nick Sheron – University of Southampton, School of Medicine
Final report

UK Alcohol Strategy
Professors Gerard Hastings and Linda Baud – University of Stirling
(Jointly funded with Cancer Research UK)
Stirling Report Health First

Cancer

Primary Liver Cancer Gene Therapy
Dr Phil Harrison – Kings College School of Medicine, Institute of Liver Studies
Final report

Development of Novel Diagnostic Makers for Bile Duct Cancer
Dr Stephen Pereira – Royal Free and UCMS
Final report

Proteomic profiling of plasma for biomarkers in primary and secondary liver cancers and benign and malignant biliary disease; using SELDI-TOF mass spectroscopy
Dr Shahid Khan – Imperial College, London
Final report

Establishment of Natural Killer Cell Therapy for Hepatocellular Carcinoma (HCC)
Professor Salim I Khakoo – University of Southampton
This is an ongoing three year research project to devise a method to stimulate natural killer cells to mount an anticancer response in Hepatocarcinoma and form the basis for a clinical trial.
Khakoo – Interim Update October 2014

Specific Liver conditions

Pathogenesis of Primary Biliary Cirrhosis
Dr J Neuberger – University Hospital Birmingham
Final research article

The molecular basis of mucosal T cell homing to the liver in Primary Sclerosing Cholangitis
Professor David Adams – University of Birmingham
Final report

Molecular action of new therapies in Obstetric Cholestasis
Professor Catherine Williamson – Imperial College, London
This is an ongoing project. Professor Williamson is researching potential safe treatments in pregnancy to protect the unborn child from bile induced damage as happens in Obstetric Cholestasis. This project has been extended for additional clinical trials on two other potential drug therapies.
Williamson – interim report March 2013

Liver fibrosis / cirrhosis

TIMP 1 and Fibrosis
Dr John P Iredale – University of Southampton, School of Medicine
Final report

Hepatocyte Proliferation and Apoptosis
Dr Chris Day – University of Newcastle, Medical School
Final report

Cloning & Biochemical Analysis of UTEBF
Dr D Mann – University of Southampton School of Medicine
Final report

Engineered forms of HGF/SF in Chronic Liver Disease
Dr E Gheradi – University of Cambridge – Dept of Oncology
Final report

How Stellate Cells Modify the Local Immune Response of the Liver
Dr A Holt – Queen Elizabeth Hospital, Birmingham
(Funded jointly with the Digestive Disorders Foundation CORE)
Final Report

Optimisation of small interfering RNAs (siRNA) targeted at the NF-kB pathway for the
treatment of liver disease
Professor Derek Mann – University of Newcastle upon Tyne
Final report

Organ donation

Organ and tissue donation: an evaluation of health care professionals’ knowledge and training and implications for education
Doctoral thesis by Timothy Collins – University of Greenwich School of Education
Final report

Social research

Epidemiology of Liver Disease in Tayside Study
Dr J F Dillon – Ninewells Hospital and Medical School Dundee
Final report

Impact and Burden of Liver Disease in the UK
Dr P Roderick – University of Southampton, School of Medicine
(Funded jointly with the Foundation for Liver Research)
Final report

LOCATE – Early detection model
Dr Nick Sheron – University of Southampton
This is an ongoing project of patient based research to implement screening to increase the earlier detection and diagnosis of liver disease. The desired outcome is an effective detection model that can be used nationally and adapted for international implementation.

Systematic Review of the Prevalence of Mildly Abnormal Liver Function Tests and Associated Health Outcomes
Sven Radcke, John F Dillon and Aja L Murray – British Liver Trust, University of Edinburgh, University of Dundee
To read the full article visit the European Journal of Gastroenterology
Abstract     Results Table 1    Results Table 2