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Immunology/autoimmune profile tests

These are tests in which your doctor looks for liver damage caused by your immune system.

They include:

AMA (anti-mitochondrial antibody)

This test is used when doctors are looking for evidence of primary biliary cholangitis (PBC), a condition in which the bile ducts become damaged. Anti-mitochondrial antibodies are found in more than 90% of patients with this disease.

SMA (smooth muscle antibody)

This is a test used to detect autoimmune diseases such as autoimmune hepatitis (AIH), which is inflammation of the liver that occurs when the immune system attacks the liver cells. A liver biopsy is usually necessary to confirm the diagnosis and stage of the disease.

LKM (liver/kidney/microsomal antibody)

This test can be positive in another type of autoimmune hepatitis.